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CAS 107868-30-4 Anabolic Steroid Hormone Exemestane Aromasin Exemestan Bulking Cycle Steroids
Usage:
Developed to help fight breast cancer, Aromasin is one of the most powerful estrogen suppressing compounds available for body builders taking anabolic steroids. Additionally, it also raises testosterone in the body, which is a bonus for bodybuilders during post-cycle-therapy.Aromasin (Exemestane) is one of those weird compounds that nobody really knows what to do with. It’s a third generation Aromatase Inhibitor (AI) just like
Arimidex (Anastrozole) and Femera (Letrozole).
Applications:
High Purity Exemestane/Aromasin/Exemestan/CAS No: 107868-30-4
the third generation aromatase inhibitors, used in the treatment of metastatic breast cancer and used as aid in the treatment of early breast cancer.Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone. These breast cancers are called hormone sensitive or hormone receptor positive and can be treated with drugs that block the effects of these hormones.
In women who have had their menopause, oestrogen is mainly produced by changing androgens (sex hormones produced by the adrenal glands) into oestrogens. This process is called aromatisation and happens mainly in the fatty tissues, muscle and the skin. It needs a particular enzyme called aromatase.
Exemestane blocks the process of aromatisation. So it lowers the amount of oestrogen in the body. In early breast cancer, taking exemestane can help to stop breast cancer coming back. In advanced breast cancer the cancer cells may grow more slowly or stop growing completely.
Hormones are chemical substances that are produced by glands in the body, which enter the bloodstream and cause effects in other tissues. For example, the hormone testosterone made in the testicles and is responsible for male characteristics such as deepening voice and increased body hair. The use of hormone therapy to treat cancer is based on the observation that receptors for specific hormones that are needed for cell growth are on the surface of some tumor cells. Hormone therapies work by stopping the production of a certain hormone, blocking hormone receptors, or substituting chemically similar agents for the active hormone, which cannot be used by the tumor cell. The different types of hormone therapies are categorized by their function and/or the type of hormone
that is affected.
Exemestane is an aromatase inhibitor. This means it blocks the enzyme aromatase (found in the body's muscle, skin, breast and fat), which is used to convert androgens (hormones produced by the adrenal glands) into estrogen. In the absence of estrogen, tumors dependent on this hormone for growth will shrink.
Note: We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. The information contained in this website is meant to be helpful and educational, but is not a substitute for medical advice.
Is exemestane a form of chemotherapy?
Exemestane is an anti-cancer hormone therapy. It is classified as an "aromatase inhibitor."
What is the success rate of exemestane?
the objective response rate (complete response + partial response) was 46% for exemestane and 31% for tamoxifen
Is it better to take exemestane at night?
Hot flashes (sudden sweating and feelings of warmth) can sometimes occur when you first start taking exemestane. This usually improves as your body adjusts to exemestane. If hot flashes are troublesome: • Try taking your exemestane at bedtime.
How should I take Aromasin?
Take Aromasin exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
Aromasin is usually taken once per day, after a meal. Try to take the medicine at the same time each day.
You will need frequent medical tests.
Your doctor may have you take extra vitamin D while you are taking Aromasin. Take only the amount of vitamin D that your doctor has prescribed.
Use Aromasin regularly to get the most benefit. You may need to keep taking take this medication for up to 5 years.
Store in the original container at room temperature away from moisture and heat.
Dosing information
Usual Adult Dose for Breast Cancer:
25 mg orally once a day
Comment:
-This drug should be administered after a meal.
Uses:
-Adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to exemestane for completion of a total of five consecutive years of adjuvant hormonal therapy.
-Treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
COA
TEST ITEMS | SPECIFICATION | RESULTS |
Description | White Crystalline Powder | White Powder |
Identification | Positive | Positive |
Assay(by HPLC) | 98.0~102.0% | 98.64% |
Absorbance(E1cm) | 465~495 | 482.5 |
Melting Point | 191~195°C | 193.5~195.0°C |
Loss On Drying | 0.5%max | 0.19% |
Specific Rotation | +288°~ +298° | +290.2° |
Residue On Ignition | 0.1%max | 0.03% |
Related Substances | Total:1.5%max | <1.3% |
Single:0.5%max | <0.4% | |
Residue Solvents | 0.2%max | 0.10% |
Heavy Metals | 20PPm max | <10PPm |
Conclusion | The specification conform with enterprise standard. |
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